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As noted, -syn pathology in PD might start in the gut (possibly triggered by a pathogen or toxin) and spread via the vagus nerve

Vitamin C can lower both Hcy and cortisol levels, reducing stress on the adrenal glands

Bounous, G., and J

We have already seen examples: transplanting microbiomes from patients into mice to induce disease features, or adding/removing single species to gauge their impact on pathology