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Regulators of PINK1 localization are potential targets for therapeutic approaches to modulate mitophagy, Chief among them is ATPase family AAA domain containing 3A (ATAD3A), a protein that regulates PINK1 importation and degradation, and autophagy and beclin 1 regulator 1 (AMBRA1) which can inhibit the action of ATAD3A and promote PINK1 stabilization on the outer mitochondrial membrane (Di Rienzo et al., 2022)