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Treating these mice with antioxidants decreased oxidative stress in the circulating cancer cells and increased their ability to metastasize

Moreover, after inhibition of Sat1, compared to AAV9-sh-Scr + MIRI group, increased TFR1 protein expression and decreased GPX4 protein expression were obviously reversed in AAV9-sh-Sat1+MIRI group (Figures 3JM)