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Description

The length of the free part of the bone was measured, as well as the length from the fixing part to the loading point

Key readout endpoints include serum ALT and AST enzyme release (hepatocyte membrane integrity), hepatic malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) as lipid peroxidation markers, H&E-stained hepatic necrosis area scoring (zones IIII centrilobular pattern), TUNEL-positive hepatocyte apoptosis count, and MPO activity as a proxy for neutrophil infiltration