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Expression of the mutant human B-crystallin in mice resulted in a cardiomyopathy, with progressive heart failure, and sudden, premature death

MyD88, myeloid differentiation factor-88

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53,54 However, it has also been suggested that the enhanced release of proinflammatory cytokines (TNF-, IL-1, IL-6, and IL-10) and chemokines (monocyte chemoattractant protein-1, macrophage inflammatory protein-2, and IL-8) further promotes hepatocyte damage, thereby aggravating necrosis