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Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells

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The hyper-oxidation of 2-Cys Prx, in particular of Prx1, adds further chaperone function to these Prxs, but depends on certain motif elements downstream of the peroxidatic cysteine residue (GGLG and YF motifs) [23, 61]