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The corresponding numbers in treated subjects were 0.71, 0.46, 0.13 and 0.08 ( p = 0.0620, adj

January 1, 2006 2006;24(1):6-8

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The inhibition of SGLT2 decreases the expression of HIF-1 in human proximal tubules under hypoxic conditions, leading to a reduction in tubular damage and interstitial fibrosis (274, 275)