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doi: 10.1111/j.1476-5381.2010.00729.x 234 GongJ-POnaiviESIshiguroHLiuQ-RTagliaferroPABruscoAet al

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Allergy risk to cobalt or preservatives (rare) Energy improvement: 24-72 hours Reticulocyte response: 3-5 days Neurological improvement: Weeks to months Hematological normalization: 4-8 weeks Maximum nerve repair: Up to 1 year Injection site reactions (15-20%) Mild diarrhea (initial doses) Itching/eczema (cobalt sensitivity) Transient anxiety (overstimulation) Headache (usually resolves quickly) Serious reactions are extremely rare

Non-volatile compounds Preclinical studies In vitro studies such as establishing cell culture models, assessing cellular viability and apoptosis, as well as investigating the modulation of signaling pathways, are preliminary steps for the in vivo studies that represent animal models of PD, including toxin-induced models (e.g., rotenone) and genetic models (e.g., SNCA transgenic mice)