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Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10)

Serum-glutamyltransferase is a predictor of incident coronary events in apparently healthy men from the general population

[20] [7] This conversion is illustrated by the reduction of peroxides (via the sulfenate as an intermediate): GSH + R 2 O 2 GSOR + ROH GSOR + GSH GSSG + ROH Net reaction: 2 GSH + R 2 O 2 GSSG + 2 ROH (R = H, alkyl) and with free radicals, forming glutathionyl radicals (GS ) that may dimerize to disulfide: GSH + R RH + GS 1/2 GSSG Thiyl radicals (such as glutathionyl radicals) are themselves oxidizing species in biology, with a single-electron reduction potential sufficient for oxidation of nucleic acids, proteins and polyunsaturated lipids

The use of PPIs is also thought to contribute to vitamin B12 deficiency (Aroda et al, 2016)