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However, there are still many details to be explored about the specific mechanism of E3 ligases involved in renal fibrosis

Adenosine signaling is terminated by uptaking adenosine from extracellular space to intracellular space and is then rapidly metabolized to inosine through adenosine deaminase (Eltzschig et al., 2006) or converted back to AMP through adenosine kinase (Morote-Garcia et al., 2008)