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In these models, the penetration kinetics of fluorescently labeled ID-ADCs can be visualized through confocal microscopy, enabling researchers to determine whether the conjugates can effectively diffuse into the hypoxic and necrotic core of the granuloma or if they are restricted to the more permeable peripheral layers ( In vitro biofilm models that replicate the shear stress and nutrition gradients of clinical situations, such as catheter-associated infections or cystic fibrosis-related lung infections, are essential for evaluating ID-ADC efficacy against biofilm-embedded bacteria

Subsequently, safety concerns remain a major bottleneck restricting the clinical translation of current research

K.ChangC.KendeH.GriersonD

doi: 10.1016/j.mcn.2017.05.005