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doi: 10.3389/frabi.2026.1767028 Received 13 December 2025 Revised 23 January 2026 Accepted 27 January 2026 Published 24 February 2026 Volume 5 - 2026 Edited by Manuel Gerardo Ballesteros Monrreal, University of Sonora, Mexico Reviewed by Anjna Kumari, Panjab University, India Madalina Adriana Bordea, University of Medicine and Pharmacy Iuliu Hatieganu, Romania Updates Copyright 2026 Debta, Sahu, Patra, Debta, Mishra and Panda

16,17 Tier 2 includes the 2 nonFDA-approved medications (gabapentin and topiramate), which have shown benefits in the treatment of AUD and can be used alone or in combination with FDA-approved agents and psychosocial interventions

Unfortunately, such decisions can lead to more unexpected negative consequences for the environment