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Thus, there were increased intraocular pressure and mydriasis, degeneration of retinal ganglion cells, optic nerve head excavation and reduction in optic nerve thickness, generalized severe irregularity of retinal vessels, faint presentation of choroidal vessels, and severe optic nerve disc atrophy in glaucomatous rats [11]

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As chelation by cholestyramine may exacerbate the deficiency, vitamin D supplements, ursodeoxycholic acid and lipid-soluble medications such as digoxin should be taken in the evening to distance them from possible chelation by cholestyramine taken with breakfast