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In the GTP-bound active form, KRAS undergoes a conformational change that enables it to interact with and activate various downstream signaling pathways, such as MAPK/ERK pathway, PI3K/AKT pathway, and RalGDS pathway [11, 29]

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In addition, in cells treated with glutathione prior to H 2 O 2 stimulation, the H 2 O 2 -induced colony formation was markedly reduced in a concentration-dependent manner (Figure 2C)