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2024 Jun 1 [cited 2025 Jul 22];36(24):2312939

Acquired Point Mutations of TKD Are Responsible for Sorafenib Resistance in FLT3-ITD Mutant AML

Because FA cannot bind fibrinogen until it is cleaved by thrombin activated at the injury site we anticipated that this region could act as a 'safety lock', minimising potential non-specific fibrinogen aggregation