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In contrast, binding of nuclear factor of activated T cells 5 to the promotor leads to downregulated Prx2 expression and increased ferroptosis in pancreatic -cells during progression of obese type 2 diabetes mellitus [155]

This differential sensitivity, where cytotoxic T cells (Teffs) are exhausted and immunosuppressive cells like regulatory T cells (Tregs) thrive, is a fundamental mechanism of immune evasion

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351 Most SERDs with acrylic side chains are discontinued after phase 1 clinical trials due to limited efficacy and uncontrollable side effects, presenting significant challenges in developing new oral SERDs