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ALZ003 can boost ROS levels even further, inhibit GPX4 to trigger ferroptosis, and recover TMZ cytotoxicity

The enzyme SUOX (Sulphite Oxidase) converts the sulfites to the more useful sulfate form

In order to reduce the side effects, p-dodecylaminophenol (p-DDAP) was further designed, and it has been demonstrated to be effective against a wide range of cancers [200]