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Timing considerations Most protocols recommend morning administration on an empty stomach

Iron deficiency is frequently secondary to SIBO, gut infections, or other inflammatory states, which explains at least in part the association between RLS and these conditions

Nowadays, because the statistical risks of false positives are quite considerable when the number of variables (such as SNPs) is large [74,75,76,77], the basis for any co-variation or correlation has to be very well established, and include separate validation sets

doi: 10.3389/fphar.2025.1570069 Received 02 February 2025 Accepted 24 February 2025 Published 24 March 2025 Volume 16 - 2025 Edited by Javier Echeverria, University of Santiago, Chile Reviewed by Kwanchayanawish Machana, Nakhon Ratchasima College, Thailand Malgorzata Kozyra, Medical University of Lublin, Poland Updates Copyright 2025 Li, Yang and Li