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Furthermore, although rare, severe toxicities like lactic acidosis are often preceded by a decline in mtDNA copy number together withrising serum lactate, suggesting that serial monitoring in high-risk individuals could allow earlier detection, although current evidence remains limited ( The utility of mtDNA extends to assessing immunological failure and exhaustion

This molecular complex plays a central role in regulating inflammatory responses in both of these conditions

In the second group, the peptide BPC-157 was injected intraperitoneally at a dose of 200 g/kg b.w

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