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On the other hand, trying to immobilize the same amount of aptamer on M-270 beads resulted in 54 g (3.34 nmol, 13.4% of starting aptamer amount, 223 pmol/mg bead) aptamer immobilization on the beads corresponding to 5.38 g aptamer/mg of the beads (see Supplementary Table S2 online)

A: This creates synergistic effect

They also demonstrated that OPMA- S -oxide is more toxic than OPMA when cell proliferation was used as an index of toxicity (IC 50 of 22 M versus 83 M)