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The chemistry

Nitric oxide: physiological functions, delivery, and biomedical applications

chinensis lignans are lipophilic and rapidly metabolized in the body, limiting systemic exposure after oral administration

3d), the pyranose glucoside is closer to the dicopper center, with its ether group interacting with CuB at a distance of 2.5 , and two hydroxyl groups forming hydrogen bonds with S361 and E326, which stabilizes the ligand binding