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4.1 Future directions: strengths, limitations and potential therapeutic interventions All literature highlighted and discussed in this review highlights some of the research that has been conducted examining the relationship between mitochondria and the gut microbiome, but it is clear that further research is required before we can utilize this relationship as a therapeutic intervention in primary mitochondrial diseases

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Each component contributes to distinct metabolic pathways that may interact within experimental models

[26] Nerve damage should be included in the treatment plan for these conditions