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MMPs cause the degradation of various components of ECM and they mediate its remodeling, which enables cell migration, and facilitates the pathogenesis processes

Listed among absolute contraindications were the following (in no specific order): History of hormone-sensitive cancer (to include endometrial, breast, cervical, and prostate cancer) Current alcohol or drug use/abuse Liver insufficiency or cirrhosis Uncontrolled preexisting chronic medical conditions (including diabetes and hypertension) Preexisting history of ischemic cardiovascular or cerebrovascular conditions Severe psychiatric disorders influencing decision-making capacity Known noncompliance with previous medical treatment therapy Ask yourself

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You have severe pelvic pain that doesnt respond to painkillers Youre bleeding between periods or after sex Book a routine appointment if: Your periods have suddenly become much heavier Youre bleeding for more than 7 days regularly Heavy bleeding is affecting your work and daily life You have signs of anaemia, like severe fatigue, pale skin, or constantly feeling cold Your doctor will ask about your menstrual cycle and how it affects your life