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doi: 10.1016/j.clnu.2024.04.016 [DOI] [PubMed] [Google Scholar] 103.Prescott SL, D'Adamo CR, Holton KF, Ortiz S, Overby N, Logan AC

Beyond the pancreas, GLP-1 receptors are expressed in the liver, adipose tissue, kidneys, and hypothalamus, which accounts for the drug class's broader effects on satiety, weight, inflammation, and renal protection.[4] The relevance to PCOS is direct: by improving insulin sensitivity and reducing hyperinsulinemia, GLP-1 receptor agonists lower the primary driver of ovarian androgen overproduction

114 and in osteosarcoma, metastatic lesions show AP-1-dependent enhancer activation