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C3G increases the expression of PINK1 and Parkin in HG- and PA-treated Net-1 cells manifested as the accumulation of LC3 in Net-1 cells and activation of PINK1/Parkin-mediated mitophagy, which in turn inhibits the excess production of ROS and O 2 , while autophagy inhibitors exert an inhibitory effect on the antioxidant capacity of C3G

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As to oxidative stress, PDA was supplemented with 5 mM H 2 O 2 , 0.5 mM TBHP, 0.68 mM cumene H 2 O 2 , or 5 mM SNP