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11 Interestingly, the antidepressant effects of ALC appeared most robust in older adults, suggesting age-related differences in mitochondrial or neurochemical pathways might mediate its psychotherapeutic actions

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A recent high-profile study found that elevated oxidative stress is a shared molecular feature of both conditions, specifically causing immune CD8 T-cells to become functionally exhausted and hyperproliferative

The selection criteria complied with age 45 years, body mass index (BMI) in the range of 2535 kg/m 2 , and diagnosis of KOA according to the clinical classification of KOA [22]