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10.1038/npp.2017.296 186

256 This dual action is partly mediated by the reduction in IGF-1 and glucose levels, thus shielding normal cells and organs from chemical toxicity

Administration of an antibiotic cocktail including ampicillin, metronidazole, and vancomycin, was found to disrupt ZO morphology while decreasing the expression of occludin and claudin-1 TJ proteins in mice (Feng et al