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[7] That preclinical promise carried the compound into a human Phase II program for postoperative ileus but the randomized, placebo-controlled trial in bowel-resection patients did not meet its primary efficacy endpoint, and clinical development was subsequently discontinued

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Ionescu and Frohman showed that CJC-1295 raised trough GH by about 7.5-fold and mean 24-hour GH by around 46 percent, without altering the frequency or amplitude of the GH pulses (Ionescu & Frohman, 2006)