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IL-1-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance

To address tuftsins rapid enzymatic degradation, researchers extended the original tetrapeptide sequence at the C-terminus with the tripeptide Pro-Gly-Pro, yielding the final heptapeptide structure Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)