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These observations indicate that nanoformulations of ibuprofen or other NSAIDs can increase effectivity within the brain and at the same time minimalize the adverse peripheral side-effects [79]

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Elevated intracellular sorbitol also provides excess nicotinamide adenine dinucleotide (NADH) to the mitochondrial electron transport chain, which is a substrate for complex I (substrate for complex I) in mitochondria and closely affects mitochondrial function and cellular energy metabolism