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Furthermore, Zhu and colleagues 15 demonstrated that the AR inhibitor AT-007 reduced sorbitol levels by approximately 50% in MNs and 35% in the Drosophila brain, mitigating sorbitol-induced toxicity

Abolhasani A, Biria D, Abolhasani H, Zarrabi A, Komeili T

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Meanwhile, we found that I178 4.60 , L181 4.63 , and M213 5.39 in cavity II are not important for the interaction with ghrelin, as their alanine mutations caused no decrease in ghrelin-induced activity, although the basal receptor activities were suppressed (Supplementary Fig