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The reason the patient responded clinically was because of the discovery of a specific pain generator, such as a myofascial TrP, joint dysfunction, or disk lesion, that responded well to some type of manual or mechanical therapy

160,161 For example, HM15211, a triple agonist developed by Hanmi Pharmaceutical in South Korea that activates GLP-1R, GIPR and GCGR has entered early clinical trials for the treatment of obesity and non-alcoholic steatohepatitis (NASH)

Esophagectomy for Esophageal Cancer

Dark spots form when melanin production becomes uneven or excessive in certain areas (a process called hyperpigmentation)