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We will discuss the relevance of pharmacological data as a function of doses or concentrations required for a given effect and of concentrations achieved in the target tissues

Nat Rev Clin Oncol 14(1):1131 Martnez-Reyes I, Chandel NS (2020) Mitochondrial TCA cycle metabolites control physiology and disease

doi: 10.1016/j.cell.2021.01.010 69 ZhangLLiZSkrzypczynskaKMFangQZhangWOBrienSAet al

[10] found some 1-methylquinolinium scaffolds modified with primary amine substitutions displaying both high passive membrane diffusion in PAMPA and high active transport membrane permeability in a bidirectional permeability assay with Caco-2 cells, and one of them (5-amino-1-methylquinolinium (5-amino-1MQ)) has significant effectiveness against diet-induced obesity