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Barriers to Drug Entry Efflux Transporters The presence of P-glycoprotein (referred to as multidrug resistance associated membrane protein) allows drugs to be transported back into the blood by ATP-dependent efflux pumps

The selected library consists predominantly of 42 six-membered rings, particularly pyridines and pyrimidines, due to their well-established reactivity profiles

Figure 2 4.1 Imaging of Gln metabolism predicts treatment response Abnormal Gln metabolism has facilitated the use of non-invasive imaging techniques for early tumor diagnosis and treatment monitoring, such as 18F-(2S,4R)-4-fluoroglutamine (18F-FGln) PET and L-(71)

doi: 10.1016/s0065-2164(09)01202-7