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Halting pro-survival autophagy by TGF inhibition in bone marrow fibroblasts overcomes bortezomib resistance in multiple myeloma patients

& Gautam, N

2.1.4 Dendritic cells: maturation, antigen presentation, and cytokine release Dendritic cells (DCs), as key antigen-presenting cells (APCs), orchestrate anti-tumor responses in the TIME ( Microbial metabolites like isodeoxycholic acid (isoDCA), converted from deoxycholic acid (DCA) by bacteria such as Eggerthella lenta and Clostridium scindens ( Similarly, secondary BAs like LCA and DCA suppress DC cytokine secretion (e.g., IL-12, IL-6) and co-stimulatory molecule expression through TGR5 activation, promoting tolerogenic phenotypes ( Nonetheless, BA effects vary by context

In the theory of TCM, RA is thought to be caused by the attack of wind, cold, damp humor, and herbs with the effect of removing wind and dampness are used to relieve pain (7, 8)