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Classical ferroptosis inducers, such as synthetic compounds like erastin and RSL3, were originally reported to inhibit the system Xc -glutathione peroxidase 4 (GPX4) antioxidant axis, triggering lipid peroxidation in cancer cells [2]

In vitro biological evaluation Cell viability Assessing the capability of MSN-PTA, MSN-PTA-SER and MSN-PTA-GLU (at concentrations of 5, 10, 25, 50, 100, 200 g/mL) on the viability of MCF-7 cells and ZR-751 at pH 7.4, the MTT assay was conducted (Fig

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