interaction of chloroacetamide electrophiles with cellular glutathion

interaction of chloroacetamide electrophiles with cellular glutathion NCBP1 stress signaling drives alternative S6K1 splicing inhibiting translation Discovery of novel benzylaniline derivatives

Name: interaction of chloroacetamide electrophiles with cellular glutathion NCBP1 stress signaling drives alternative S6K1 splicing inhibiting translation Discovery of novel benzylaniline derivatives
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Discovery of novel benzylaniline derivatives containing chloroacetamide as GPX4 inhibitors with potential efficacy in triple negative breast cancer ScienceDirect Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis Chevallier 2020 Biotechnology and Bioengineering Wiley Online Library Selective covalent targeting of GPX4 using masked nitrile oxide electrophiles Nature Chemical Biology Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis induced tumor cell death ScienceDirect

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Many people with depression, especially those who have experienced early childhood stress, have been found to have increased signaling along the hypothalamic-pituitary-adrenal (HPA) axis

About half of the HDGEC participants had started experiencing symptoms recently (early manifest HD) while the other half had no symptoms at the time of the study (premanifest HD)