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Mouse husbandry For the isolation of mitochondria and proximal tubular cells, kidneys were excised from cadavers of 812-week-old male and female wild type C57/BJ and C57/BJ crossed with 129S6 used for other experimental purposes not related to this study, following the principles of the 3Rs (Replacement, Reduction and Refinement) of animal experimentation

(Griffiths and Flatters, 2015) reported that the selective pharmacological modulation of the mitochondrial electron transport chain (ETC) (at level of complex I or III) in vivo could also reverse or attenuate the above-mentioned symptoms, but with deleterious effects on motor coordination in the case of complex I inhibition at 3 and 24 h after paclitaxel administration

doi: 10.1016/j.molmed.2014.05.002

Jan 2021;45(1):e13543