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IMiDs treatment has been shown to decrease HIF-1 expression within the BM indicating that HIF-1 could also serve as a target in MM (128)

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The engine driving the ship: metabolic steering of cell proliferation and death

In addition, FGF21 treatment significantly reduces ACSL4 and iron deposition, increases GPX4 expression, and reduces ferroptosis in nerve cells by activating the FGFR1/-Klotho pathway