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This increase in norepinephrine stimulates -adrenergic receptors in the brains satiety center, inducing a stress-response signal that diminishes hunger

However, these membrane permeabilizing agents are not nutrient metabolites, play no essential metabolic role, and in fact they typically impair membrane function

This recommendation was based primarily on preventing hypotension (low blood pressure), and secondarily, on preventing the fishy body odor due to increased excretion of trimethylamine

The same authors found that the L-tyrosine analogue (S)--fluoromethyltyrosine (AFMT), a nontoxic selective inhibitor of TDC (but not AADC), inhibited gut microbial levodopa decarboxylation in vitro