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Interestingly, defects of TTLL5, a glutamylase, leading to hypoglutamylation on its substrates is also leading to photoreceptor degeneration (Sun et al, 2016), showing that the correct adjustment of physiological glutamylation levels is crucial to maintain the correct function of photoreceptor cells

The original PD model was mainly developed from data collected in rodents and primates with tract-tracing invasive approaches, immunochemistry and in situ hybridization techniques (Quartarone et al