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(2019) 29:627637.e5

doi: 10.1371/journal.ppat.1010166 42 WagnerE.FagerlundA.ThalguterS.JensenM

The idea that the insula wrongly assigns salience to painful stimuli, contributing to heightened pain perception through increased insula activity in Crohns disease, is further supported by the fact that increased functional connectivity (FC) between the SN and the ECN has also been observed in IBD patients ( These findings suggest that the elevated levels of Glx and Gln observed in our study could reflect increased insula activity in Crohns disease patients

3 DHA is rapidly absorbed in cells and tissues through an unknown transporter and then converted to dihydroxyacetone phosphate by triose kinase/flavin mononucleotide (FMN) cyclase, after which it can then be incorporated into many different metabolic pathways, including glycolysis