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Under endotoxin shock, the activity of the key antioxidant enzyme Glutathione Peroxidase 4 (GPX4) in alveolar epithelial cells decreases significantly, leading to the lethal accumulation of lipid peroxides on membrane systems (54)

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The E6 and E7 proteins downregulate TLR9 expression and inhibit NF-B activity, while the E1 protein interferes with TRIF-dependent signaling, thereby attenuating IRF3 phosphorylation and reducing IFN- synthesis [118, 191]

However, in recordings for GluN2C- and GluN2D-containing receptors the current did not show a clear peak and instead the current continued to develop gradually over several seconds