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It is found that increase glutathione interacts with melanin production, the main pigment resulting in pigmentation of the skin and darker skin tone

14 In a meta-analysis of 4 observational studies with 28,000 patients, the risk of non-melanoma skin cancer was significantly higher among patients exposed to these drugs

[] While these metals do have essential biological functions, they are however needed only in miniscule amounts, and should an excessive intake of these metals occur or accumulate, their presence can result in cellular and tissue damage, which could result in disease and disorders among humans

Breathing in copper dust or fumes can cause metal fume fever.