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Upregulation of miR-21 or interference with BDH2 expression enhanced TET protein activity, resulting in decreased DNA methylation of the BCL6 gene promoter, ultimately promoting BCL6 gene expression [26]

Nature 588 , 174179 (2020)

Phosphoproteomic data analysis The analysis of phosphoproteomic data was generally followed as outlined in the paper introducing PhosR 51 , which employs a multi-step framework comprising two major components: the first component is the kinaseSubstrateScore function, which evaluates a given phosphosite by integrating kinase recognition motifs and phosphoproteomic dynamics, and the second component is the kinaseSubstratePred function, which combines the scores from the first component for predicting kinase-substrate relationships using an adaptive sampling-based positive-unlabeled learning method 90

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