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A deeper understanding of these mechanisms can pave the way for more personalized and effective treatments, ultimately improving patient outcomes and reducing mortality in this high-risk population

Future studies should focus on developing combinatorial strategies, such as identifying optimal pairings of exercise modalities (e.g., high-intensity interval training versus moderate-intensity endurance training) with specific classes of Chinese herbal medicine, elucidating the cross-regulation mechanisms within the Nrf2/NF-B/AMPK signaling network, and establishing individualized intervention protocols that integrate exercise with botanical treatment for ALD patients