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However, the FDA has issued a strong warning: certain bulk drug substances used in compounding may carry serious safety risks and, in some cases, may violate federal law

22b.2.5 Urinary methylmalonic acid excretion Vitamin B12 serves as a cofactor for methylmalonyl CoA mutase (EC 5.4.99.2) as noted earlier.This enzyme acts in the conversion of methylmalonyl CoA to succinyl CoA (Figure 22b.7)