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Dobric A, De Luca SN, Seow HJ, Wang H, Brassington K, Chan SMH, Mou K, Erlich J, Liong S, Selemidis S, et al

The incubation with antioxidants abrogated the anti-proliferative response, suggesting that the oxidative stress induced by fumarate accumulation is responsible for the induction of senescence