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NF-B, PI3K/AKT, and MAPK pathways collectively regulate intracellular GSH and antioxidant capacity, helping tumors evade ROS-dependent therapies

While a comprehensive cytokine profile was not assessed, the blockade of this central pathway implies an indirect suppression of TGF-driven pro-inflammatory cytokine cascades, thereby contributing to the overall attenuation of hepatic fibrosis

The research demonstrated that CD4+ T cells are responsible for neurodegeneration, as CD4+ T lymphocytes have been found as key mediators in dopaminergic neuronal death in the MPTP mouse model of PD (66)