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10.1002/mnfr.201200182 127

Gold PW, Wong ML (2021) Re-assessing the catecholamine hypothesis of depression: the case of melancholic depression

Intracellular mechanisms suggest that post internalization in olfactory sensory neurons, the drug is transported along the axon to the synapse, where it is released into the olfactory bulb, allowing final delivery to the brain

The existence of the remnant receptor pathway was suggested by the fact that patients with homozygous FH, who completely lack LDLR function, have severely elevated levels of LDL-C but normal blood levels of triglycerides